In the bowl of a stand mixer, stir together water, flour, yeast, and salt. Allow mixture to sit in a warm place for at least 30 minutes and up to 2 hours. The surface should look bubbly and like a sponge!
With a dough hook fitted to the mixer and the machine on low, add sugar, evoo, scraped vanilla bean, eggs and yolks.
Add flour, ½ cup at a time until the dough is smooth and tacky but not too wet or sticky.
Cover and allow dough to rest for 1 to 2 at room temp until it doubles in size. Alternatively, you can cover and allow it to slowly rise in the refrigerater overnight.
Preheat oven to 350°F. Line two 9 inch loaf pans with parchment paper.
Divide risen dough into 4 equal parts. Roll out each piece into an 8- x 14-inch rectangle.
Shmear each rectangle with ¼ of cranberry mixture. Roll the rectangle, jelly-roll style and pinch seam together.
Twist 2 pieces together and place into prepared 9 inch loaf pan.
Repeat with the other two pieces of dough. Twist them together and place into a greased 9 inch loaf pan.
Allow babkas to rise for about 1 hour or until doubled in size.
Brush babkas with egg wash and bake at 350°F for 45 to 55 minutes until browned.
Drizzle babkas with orange glaze before serving.